MMP7 cleaves remyelination-impairing fibronectin aggregates and its expression is reduced in chronic multiple sclerosis lesions
نویسندگان
چکیده
منابع مشابه
Fibronectin aggregation in multiple sclerosis lesions impairs remyelination.
Remyelination following central nervous system demyelination is essential to prevent axon degeneration. However, remyelination ultimately fails in demyelinating diseases such as multiple sclerosis. This failure of remyelination is likely mediated by many factors, including changes in the extracellular signalling environment. Here, we examined the expression of the extracellular matrix molecule ...
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ژورنال
عنوان ژورنال: Glia
سال: 2018
ISSN: 0894-1491
DOI: 10.1002/glia.23328